Originally posted on https://mindzymes.com/prl-8-53/


PRL-8-53 is a Nootropic drug discovered in the 1970’s by Dr. Nikolaus Hansl of Creighton University. Although there have been no modern day studies on the drug, based on Dr. Hansl’s lone human trial, there seems to be strong evidence that PRL-8-53 can improve recall and verbal memory function. Thousands of personal accounts gathered on websites like Reddit have corroborated those original findings.

PRL-8-53 was first created to enhance the memory and learning abilities of its users. It also has notable effects, such as reducing fatigue and helping to fight depression, anxiety, and insomnia. It is not a prescription drug; however, it’s always a good idea to consult your doctor before you start using any drug.

Studies into PRL-8-53

In Dr. Hansl’s original 1978 double-blind study of 47 healthy adults, the participants who took a 5mg dose of PRL-8-53 were able to better recall test questions in a word recollection test than the ones who took a placebo pill. Additionally, many of the participants were better able to recite the order of words up to four days after the trial.

Besides his original study, Dr. Hansl also conducted a number of trials that went unpublished, but are still available in his personal journals. In these journals, Dr. Hansl describes how PRL–8-53 was able to statistically improve user’s scores in a geometric pattern exercise that revolves around cognitive capabilities.

Simply put, a group of participants were asked to look at various geometric patterns and were asked to recollect their memory of them and draw them back. This test showed a good statistical improvement, but there is a lot of room for further studies and experiments, as the possibilities seem promising.

Other tests that Dr. Hansl conducted during this time included ones focused on the verbal fluency of PRL-8-53 users. This test required participants to use dots and letters to form words under varying sets of physical and mental conditions.

In one test, the participants were shown the letters “U” and “R” and were asked to turn these letters into words by adding letters before and after them. They were given dots that will represent the number of letters they can put in. The results from this test showed that participants that were on PRL–8-53 achieved better results while being able to form more words under different conditions.

Tests like these could help to prove that PRL-8-53 has the ability to improve cognitive function and help people think more clearly, and with greater focus. However, since most of Dr. Hansl’s research remains unpublished, it must be noted that these findings are considered unverified by the scientific community and are looked at as anecdotal.

As I mentioned, unfortunately there are no ongoing research studies into PRL-8-53. But since 1978, Nootropic experts and enthusiasts have claimed that PRL-8-53 has the potential to be the best memory booster on the market.

In 2013, a study conducted by the Erowid Experience Vault also revealed that a first-time user of PRL-8-53 found it easier to initiate non-awkward conversations throughout the day by taking just 10mg of the drug. In addition, users on sites like Reddit have posted countless success stories and anecdotes describing the positive effects of PRL-8-53.

How Does PRL-8-53 Work?

Derived from benzoic acid and benzylamine, PRL-8-53’s exact mechanism of action has not been fully documented. With that said, it is known to act upon several neurotransmitters at once. Benzoic acid is a naturally occurring compound found in many foods, including berries, plants, and milk products. When consumed in excess, the human body recognizes it as a waste product and it is typically removed through urination.

PRL-8-53 probably works by increasing and improving the production and secretion of acetylcholine, a powerful neurotransmitter in your brain. PRL-8-53 is also thought to increase the levels of dopamine in the body, which will increase memory and learning abilities, reduce fatigue, anxiety, and depression symptoms, and even help with insomnia.

Because of these well-documented effects, PRL-8-53 has also been used by psychonauts and researchers who are looking to investigate the effects of Nootropic drugs on the subconscious mind.

Suggested Dosage and Side Effects

According to most manufacturers, the recommended dose of PRL-8-53 is between 10 to 20 mg of powdered product per day. In the aforementioned study from the 1970’s, all participants received a total of 5mg of PRL–8-53 exactly 2 hours before they were subjected to the test.

This dosage is not known to generate any side effects among its users, so it should be considered a good “starting point”, especially if you are new to Nootropics. Officially, there are no known side effects from the regular use of PRL-8-53.  Naturally, the lack of information is due to the absence of clinical trials and modern testing data. So for now, you should be sure to consult your doctors and get his/her opinion before you buy PRL-8-53 or any other Nootropic.

As with all Nootropics, PRL-8-53 can also be “stacked”, or compounded into capsules with other supplements to get even richer benefits. It is not uncommon for memory enhancing Nootropics to be combined with other supplements; however, given the lack of verified research compared to other drugs like it, we don’t suggest stacking PRL-8-53 with other memory-boosting Nootropics. That being said, you can try it out with different substances that don’t have similar effects.

The Bottom Line

If you are looking for a natural way to improve your memory and enhance your learning abilities, then PRL-8-53 is a terrific supplement. A single daily dose can gradually increase your dopamine and acetylcholine levels, which can help give you the boost you’ve been looking for to study for that test, finish that job, or finally focus on your mental and physical wellness.

Of course, it is important to remember that there is a serious lack of scientific research into PRL-8-53 when compared to other Nootropics, and at this point we are relying mostly on anecdotal evidence to draw our conclusions. But the consistently promising results from experienced users have led to a groundswell of enthusiasm for PRL-8-53 that we don’t often see, so we’d put this drug on your radar if you aren’t quite willing to give it a try.


These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.