The Centeno Schultz Clinic Announces the Publication of a New Randomized Controlled Trial on the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate vs Exercise Therapy Resulted in an 89% Improvement in Function & Pain While the Associated MRI Analysis Demonstrated a Decrease in Tear Size in Most Patients 


Broomfield, CO – March 11, 2020 – The Centeno-Schultz Clinic, the practice where many orthopedic stem cell procedures were pioneered is pleased to announce the publication of our randomized controlled study on the use of Bone Marrow Concentrate (BMC) and Platelet Rich Plasma (PRP) to treat Rotator Cuff tears vs. exercise therapy.  

The rotator cuff is a structure in your shoulder that both moves and stabilizes the joint. Rotator cuff tears are commonly associated with injury and/or age-related degeneration.  Rotator cuff disorders (RCD) can be found in up to 50% of people over 50 years old. Rotator cuff tears account for 4.5 million physician visits and over 250,000 surgical repairs annually in the US. Unfortunately, there is little evidence that surgical intervention will result in a better outcome compared to conservative care such as physical therapy.  

The Centeno-Schultz study was funded by Regenexx and included patients with partial to complete non-retracted rotator cuff tears who would otherwise be surgical candidates. They received either a precise ultrasound-guided injection of high dose bone marrow concentrate or physical therapy. This was a cross-over randomized controlled trial where patients could cross form PT into the injection group. 

“We are excited to announce our recent midterm randomized controlled study publication on treating rotator cuff tears. At 2 years post-treatment, patients reported an 89% improvement in pain (utilizing the numeric pain scale or NPS) and function (utilizing the DASH assessment). In addition, MRI review demonstrated a decrease in the size of most tears with our same-day stem cell treatment. As the first clinic in the world to use stem cells to treat many orthopedic conditions, we look forward to continuing to lead this field of interventional orthobiologics and to take a data-driven approach to patient care.” stated Christopher J. Centeno, MD

These findings suggest that ultrasound-guided bone marrow concentrate, and platelet product injections are a safe and useful alternative to conservative exercise therapy of torn, non-retracted rotator cuff tears.   This trial is registered with NCT01788683.  To read the entire paper or any of the Centeno-Schultz published papers visit

About Centeno Schultz Clinic: Centeno Schultz Clinic has two locations, in Broomfield and Lone Tree, Colorado. With over 15 years’ experience, the Centeno Schultz Clinic is the premier stem cell and Regenerative Medicine clinic in the world. The Centeno Schultz Clinic utilizes a data-driven approach to patient care, which is only possible through the decades of patient outcome information in the registry, the university level lab and the commitment of our board-certified doctors.   For more information, please visit our website at, and for the latest clinic updates connect with us on Facebook or Instagram

Media Contact:

Leslie McConnon
403 Summit Blvd, Ste 201
Broomfield, CO
(303) 429-6448